The main motivation for this workshop is to discuss in depth the high-energy implications of the experimental anomalies in B-meson semileptonic decays. The main focus will be on the models of new physics that can explain the anomalies, but could also address some of the other inadequacies of the SM (naturalness, dark matter, flavor puzzle, ...) and develop a road-map for the systematic search and discovery of the putative new particles. This includes the high pT searches at the LHC and the prospects for any of the possible future facilities such as HE-LHC, FCC, CLIC, etc for heavy new physics, searches in low energy experiments for light mediators and studying complementarity with other flavor processes.